Entrez PubMed

1: Genomics. 1999 Aug 15;60(1):31-9. Related Articles, Links: Identification of candidate Drosophila olfactory receptors from genomic DNA sequence.

Gao Q, Chess A.

Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts, 02142, USA.

We have taken advantage of the availability of a large amount of Drosophila genomic DNA sequence in the Berkeley Drosophila Genome Project database ( approximately 1/5 of the genome) to identify a family of novel seven transmembrane domain encoding genes that are putative Drosophila olfactory receptors. Members of the family are expressed in distinct subsets of olfactory neurons, and certain family members are restricted to distinct portions of the olfactory system. This pattern of expression has interesting similarities to and differences from the expression patterns observed for olfactory receptors in vertebrates. The Drosophila olfactory system is simpler than mammalian systems, yet it is complex enough to present a fascinating system in which to study neural information processing. Moreover, the powerful genetic manipulations available in Drosophila, when combined with electrophysiological and behavioral analyses, make this an attractive model system in which to study olfactory discrimination. Copyright 1999 Academic Press.

PMID: 10458908 [PubMed - indexed for MEDLINE]